Pharmaniaga Morphine Sulphate Drug Interactions

Serious and sometimes fatal reaction have occurred when given to patients already receiving monoamine oxidase inhibitors. Depressant effects of morphine are enhanced by CNS depressants such as alcohol, anaesthetics, hypnotics and sedatives, tricyclic antidepressants and phenothiazines. Opioid analgesics with some antagonist activity such as buprenorphine, butorphenol, nalbuphine or pentazocine may precipitate withdrawal symptoms in patients who have recently used morphine. The actions of opioid may in turn affect the activities of other compounds e.g. their gastro-intestinal effects may delay absorption as with maxiletine or may be counter-active as with metoclopramide.
Incompatibilities: Morphine sulphate is physically incompatible with acyclovir sodium, aminophylline, amobarbital sodium, cefepime hydrochloride, chlorothiazide sodium, floxacillin sodium, furosemide, gallium nitrate, heparin sodium, meperidine hydrochloride, meperidine sodium, methicillin sodium, minocycline hydrochloride, pentobarbital sodium, phenobarbital sodium, phenytoin sodium, sargramostim, sodium bicarbonate, thiopental sodium.